Xalkori
producent: Pfizer
innehÄller
Xalkori Àr ett lÀkemedel för immunterapi (enzymhÀmmare).Aktiva Àmnen
Crizotinib
ansökan
Xalkori anvÀnds för att behandla vissa former av lÄngvarig cancer.
MÄste endast levereras frÄn sjukhus.
dos
Finns som kapslar.
- vuxna. Vanligtvis 250 mg tvÄ gÄnger om dagen.
Obs!
- Kapslarna ska svÀljas hela.
- Kapslarna mÄste inte tuggas eller öppnas.
- Vid mycket dÄligt fungerande njurar ska dosen minskas till 250 mg en gÄng om dagen.
Eventuella biverkningar
Mycket vanlig (över 10%) | Minskad aptit, trötthet DiarrĂ©, förstoppning, illamĂ„ende, leverbiverkningar, buksmĂ€rta, krĂ€kningar, smakförĂ€ndringar Svullnad pĂ„ grund av vĂ€tskans ackumulering i kroppen, lĂ„ngsam puls Blodbrist, Ăkad risk för infektion pĂ„ grund av brist pĂ„ vita blodkroppar Nervsystemet, yrsel hudutslag synstörningar |
Vanlig (1-10%) | MatsmĂ€ltningsbesvĂ€r, esofageal störning HjĂ€rtsvikt, lungsjukdom, effekter av ekg Minskat manligt könshormon i blodet synkope Cyster i njurarna, Ăkad kreatinin i blodet |
Mindre vanliga (0,1-1%) | DĂ„rligt fungerande lever, tarm i tarmen njursvikt |
graviditet
Kan endast anvÀndas under vissa förhÄllanden.- Det finns begrÀnsad erfarenhet av anvÀndningen av agenset för gravida kvinnor. Skall endast anvÀndas i speciella fall efter samrÄd med specialist.
amning
AnvÀnd inte denna text. Denna text skiljer sig frÄn företagets godkÀnda produktinformation (produktsammantrÀde).trafik
Ingen varning.givarblod
Falla inte. Givaren mÄste tillkÀnnages av donatorpoolen.effekt
- Fungerar genom att hÀmma ett enzym,tyrosin, vilket ökar tillvÀxten av cancercellerna.
- Halveringstiden i blodet (TÂœ) Ă€r ungefĂ€r 42 timmar.
farmaceutiska former
Kapslar, hÄrda. 1 kapsel innehÄller 200 mg eller 250 mg crizotinib.
SĂ€rskilda varningar
- LÀkemedlet ska anvÀndas med försiktighet i dÄligt fungerande lever och i viss lung- eller hjÀrtsjukdom.
- Allvarlig synförlust har observerats med anvÀndning av Xalkori. Genom nyinsjuknade svÄr synnedsÀttning behandling ska avbrytas och göras grundligt ögonundersökning.
- Större mÀngder grapefruktjuice kan öka lÀkemedlets effekt.
AnvÀndning av andra lÀkemedel
Det Àr viktigt att informera din lÀkare om alla lÀkemedel du tar.
- Antibiotika (klaritromycin, erytromycin), itrakonazol (fungicid) och proteasinhibitorer (anti-HIV) kan förstÀrka effekten av Xalkori.
- Epileptiska lÀkemedel (karbamazepin, fenobarbital och fenytoin), kortikosteroider (prednisolon) och agenter tuberkulos (rifabutin och rifampicin) och naturlÀkemedel som innehÄller johannesört kan minska effekten av Xalkori.
Grants, leverans, förpackning och priser
subventioner | utlÀmning | Doseringsform och styrka | packning | Pris i kr. |
TillhandahÄlls endast till sjukhus. Om inte annat följer av lÀkemedel i doserings grupp A | hÄrda kapslar 200 mg | 60 st. (Blister) | 48.970,90 | |
TillhandahÄlls endast till sjukhus. Om inte annat följer av lÀkemedel i doserings grupp A | hÄrda kapslar 250 mg | 60 st. (Blister) | 48.970,90 |
fÀrgÀmnen
JÀrnoxider och jÀrnhydroxider (E172)
Titandioxid (E171)
FAQ - 💬❓ Is Xalkori chemotherapy?👉 Xalkori capsules ;is the trade name for the generic chemotherapy drug Crizotinib. In some cases, health care professionals may use the trade name Xalkori when referring to the generic drug name Crizotinib. Drug type: Xalkori capsules is a targeted therapy. ❓ What kind of drug is Xalkori?👉 Xalkori is a prescription medicine used to treat the symptoms of Non-Small Cell Lung Cancer. Xalkori may be used alone or with other medications. Xalkori belongs to a class of drugs called Antineoplastics, Tyrosine Kinase Inhibitor; Antineoplastics, Anaplastic Lymphoma Kinase Inhibitor. ❓ How effective is Xalkori?👉 The percent of people using Xalkori who saw a tumor response (like tumor shrinking) was 66% (the overall response rate or ORR). One patient had a complete response, and 64% of patients (32/50) had a partial response. ❓ Can Xalkori cure lung cancer?👉 These gene fusions create an overactive protein that causes cancer. By blocking the effects of these fusion genes, Xalkori helps slow the growth of lung cancer cells and causes cancer cells to die. Because of this, targeted therapy is a preferred treatment option for people who have ALK+ or ROS1+ NSCLC. ❓ How much does Xalkori cost per month?👉 We only charge a flat monthly fee of $49 per medication for our services. ❓ How long does it take for Xalkori to work?👉 Official answer. We can estimate that Xalkori starts to work within approximately 2 months from graphs plotting progression-free survival, but most trials report on how long Xalkori keeps a person's cancer from getting worse, not how quickly it works. This is called progression-free survival. ❓ Can non small cell lung cancer go into remission?👉 Complete remission of advanced NSCLC can be achieved using the combination of oral icotinib and BAI chemotherapy. Core tip: Few patients can undergo surgery for treatment of non-small-cell lung cancer because of advanced disease or poor pulmonary function. ❓ How much does Entrectinib cost?👉 Roche's newly-approved tumor agnostic therapy entrectinib (Rozlytrek) has been priced at approximately $17,050 per month, Reuters reported. ❓ How do you take Xalkori?👉 The usual starting dose is one 250 mg XALKORI capsule, taken twice a day: Take one capsule in the morning and one capsule in the evening at about the same time every day. ❓ How long do you live with non-small cell lung cancer?👉 The 5-year survival rate for men is 18%. The 5-year survival rate for women is 25%. The 5-year survival rate for NSCLC is 26%, compared to 7% for small cell lung cancer. However, it is important to note that survival rates depend on several factors, including the subtype of lung cancer and the stage of disease. ❓ How fast does non-small cell lung cancer spread?👉 How quickly does non-small cell lung cancer grow? Scientists often measure the growth rate of a tumor in doubling time . That's how much time it takes for a group of cancer cells to double in size. A 2019 study found that the median doubling time of NSCLC was 230 days . 👉 Indications. XALKORI is a prescription medicine used to treat people with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. It is not known if XALKORI is safe and effective in children. 👉 What is Xalkori? Xalkori ( crizotinib) is a cancer medication that interferes with the growth and spread of cancer cells in the body. Xalkori is used to treat non-small cell lung cancer that has spread to other parts of the body. Xalkori may also be used for purposes not listed in this medication guide. 👉 Xalkori is a prescription medicine that is used to treat people with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. It is not known if Xalkori is safe and effective in children. 👉 The active substance in Xalkori, crizotinib, is an RTK inhibitor. It works mainly by blocking the activity of ALK or ROS1, including when the genetic change is present, thereby reducing the growth and spread of the cancer in ALK-positive or in ROS1-positive NSCLC. |