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Xalkori


producent: Pfizer

innehÄller

Xalkori Àr ett lÀkemedel för immunterapi (enzymhÀmmare).

Aktiva Àmnen

Crizotinib


ansökan

Xalkori anvÀnds för att behandla vissa former av lÄngvarig cancer.

MÄste endast levereras frÄn sjukhus.


dos

Finns som kapslar.

  • vuxna. Vanligtvis 250 mg tvĂ„ gĂ„nger om dagen.

Obs!

  • Kapslarna ska svĂ€ljas hela.
  • Kapslarna mĂ„ste inte tuggas eller öppnas.
  • Vid mycket dĂ„ligt fungerande njurar ska dosen minskas till 250 mg en gĂ„ng om dagen.

Eventuella biverkningar

Mycket vanlig (över 10%)

Minskad aptit, trötthet

Diarré, förstoppning, illamÄende, leverbiverkningar, buksmÀrta, krÀkningar, smakförÀndringar

Svullnad pÄ grund av vÀtskans ackumulering i kroppen, lÄngsam puls

Blodbrist, Ökad risk för infektion pĂ„ grund av brist pĂ„ vita blodkroppar

Nervsystemet, yrsel

hudutslag

synstörningar

Vanlig (1-10%)

MatsmÀltningsbesvÀr, esofageal störning

HjÀrtsvikt, lungsjukdom, effekter av ekg

Minskat manligt könshormon i blodet

synkope

Cyster i njurarna, Ökad kreatinin i blodet

Mindre vanliga (0,1-1%)

DĂ„rligt fungerande lever, tarm i tarmen

njursvikt



graviditet

Kan endast anvÀndas under vissa förhÄllanden.
  • Det finns begrĂ€nsad erfarenhet av anvĂ€ndningen av agenset för gravida kvinnor. Skall endast anvĂ€ndas i speciella fall efter samrĂ„d med specialist.

amning

AnvÀnd inte denna text. Denna text skiljer sig frÄn företagets godkÀnda produktinformation (produktsammantrÀde).

trafik

Ingen varning.

givarblod

Falla inte. Givaren mÄste tillkÀnnages av donatorpoolen.

effekt

  • Fungerar genom att hĂ€mma ett enzym,tyrosin, vilket ökar tillvĂ€xten av cancercellerna.
  • Halveringstiden i blodet (TÂœ) Ă€r ungefĂ€r 42 timmar.

farmaceutiska former

Kapslar, hÄrda. 1 kapsel innehÄller 200 mg eller 250 mg crizotinib.


SĂ€rskilda varningar

  • LĂ€kemedlet ska anvĂ€ndas med försiktighet i dĂ„ligt fungerande lever och i viss lung- eller hjĂ€rtsjukdom.
  • Allvarlig synförlust har observerats med anvĂ€ndning av Xalkori. Genom nyinsjuknade svĂ„r synnedsĂ€ttning behandling ska avbrytas och göras grundligt ögonundersökning.
  • Större mĂ€ngder grapefruktjuice kan öka lĂ€kemedlets effekt.

AnvÀndning av andra lÀkemedel

Det Àr viktigt att informera din lÀkare om alla lÀkemedel du tar.
  • Antibiotika (klaritromycin, erytromycin), itrakonazol (fungicid) och proteasinhibitorer (anti-HIV) kan förstĂ€rka effekten av Xalkori.
  • Epileptiska lĂ€kemedel (karbamazepin, fenobarbital och fenytoin), kortikosteroider (prednisolon) och agenter tuberkulos (rifabutin och rifampicin) och naturlĂ€kemedel som innehĂ„ller johannesört kan minska effekten av Xalkori.

Grants, leverans, förpackning och priser

subventionerutlÀmningDoseringsform och styrkapackningPris i kr.
TillhandahÄlls endast till sjukhus. Om inte annat följer av lÀkemedel i doserings grupp AhÄrda kapslar 200 mg60 st. (Blister)48.970,90
TillhandahÄlls endast till sjukhus. Om inte annat följer av lÀkemedel i doserings grupp AhÄrda kapslar 250 mg60 st. (Blister)48.970,90


fÀrgÀmnen

JÀrnoxider och jÀrnhydroxider (E172)

Titandioxid (E171)



Xalkori

FAQ - 💬

❓ Is Xalkori chemotherapy?

👉 Xalkori capsules ;is the trade name for the generic chemotherapy drug Crizotinib. In some cases, health care professionals may use the trade name Xalkori when referring to the generic drug name Crizotinib. Drug type: Xalkori capsules is a targeted therapy.

❓ What kind of drug is Xalkori?

👉 Xalkori is a prescription medicine used to treat the symptoms of Non-Small Cell Lung Cancer. Xalkori may be used alone or with other medications. Xalkori belongs to a class of drugs called Antineoplastics, Tyrosine Kinase Inhibitor; Antineoplastics, Anaplastic Lymphoma Kinase Inhibitor.

❓ How effective is Xalkori?

👉 The percent of people using Xalkori who saw a tumor response (like tumor shrinking) was 66% (the overall response rate or ORR). One patient had a complete response, and 64% of patients (32/50) had a partial response.

❓ Can Xalkori cure lung cancer?

👉 These gene fusions create an overactive protein that causes cancer. By blocking the effects of these fusion genes, Xalkori helps slow the growth of lung cancer cells and causes cancer cells to die. Because of this, targeted therapy is a preferred treatment option for people who have ALK+ or ROS1+ NSCLC.

❓ How much does Xalkori cost per month?

👉 We only charge a flat monthly fee of $49 per medication for our services.

❓ How long does it take for Xalkori to work?

👉 Official answer. We can estimate that Xalkori starts to work within approximately 2 months from graphs plotting progression-free survival, but most trials report on how long Xalkori keeps a person's cancer from getting worse, not how quickly it works. This is called progression-free survival.

❓ Can non small cell lung cancer go into remission?

👉 Complete remission of advanced NSCLC can be achieved using the combination of oral icotinib and BAI chemotherapy. Core tip: Few patients can undergo surgery for treatment of non-small-cell lung cancer because of advanced disease or poor pulmonary function.

❓ How much does Entrectinib cost?

👉 Roche's newly-approved tumor agnostic therapy entrectinib (Rozlytrek) has been priced at approximately $17,050 per month, Reuters reported.

❓ How do you take Xalkori?

👉 The usual starting dose is one 250 mg XALKORI capsule, taken twice a day: Take one capsule in the morning and one capsule in the evening at about the same time every day.

❓ How long do you live with non-small cell lung cancer?

👉 The 5-year survival rate for men is 18%. The 5-year survival rate for women is 25%. The 5-year survival rate for NSCLC is 26%, compared to 7% for small cell lung cancer. However, it is important to note that survival rates depend on several factors, including the subtype of lung cancer and the stage of disease.

❓ How fast does non-small cell lung cancer spread?

👉 How quickly does non-small cell lung cancer grow? Scientists often measure the growth rate of a tumor in doubling time . That's how much time it takes for a group of cancer cells to double in size. A 2019 study found that the median doubling time of NSCLC was 230 days .

👉 Indications. XALKORI is a prescription medicine used to treat people with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. It is not known if XALKORI is safe and effective in children.

👉 What is Xalkori? Xalkori ( crizotinib) is a cancer medication that interferes with the growth and spread of cancer cells in the body. Xalkori is used to treat non-small cell lung cancer that has spread to other parts of the body. Xalkori may also be used for purposes not listed in this medication guide.

👉 Xalkori is a prescription medicine that is used to treat people with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. It is not known if Xalkori is safe and effective in children.

👉 The active substance in Xalkori, crizotinib, is an RTK inhibitor. It works mainly by blocking the activity of ALK or ROS1, including when the genetic change is present, thereby reducing the growth and spread of the cancer in ALK-positive or in ROS1-positive NSCLC.


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