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OtezlaÂź


producent: Celgene Nordic

innehÄller

OtezlaŸ Àr ett lÀkemedel för psoriasis. Immunsuppressivt medel.

Aktiva Àmnen

Apremilast


ansökan

OtezlaŸ anvÀnds för allvarliga fall av psoriasis och psoriasisartrit, dÀr annan behandling inte har haft tillrÀcklig effekt.

Kan endast erhÄllas frÄn sjukhus eller specialist.


dos

Finns som tabletter.

vuxna

  • 30 mg tvĂ„ gĂ„nger om dagen.
  • I mycket dĂ„ligt fungerande njurar. 30 mg en gĂ„ng om dagen.
  • Initieringen av behandlingen sker med ett specialpaket av produkten som innehĂ„ller bĂ„de 10 mg, 20 mg och 30 mg tabletter) enligt följande schema:
Dag 1Dag 2Dag 3Dag 4Dag 5Dag 6
morgonmorgonkvÀllmorgonkvÀllmorgonkvÀllmorgonkvÀllmorgonkvÀll
10 mg10 mg10 mg10 mg20 mg20 mg20 mg20 mg30 mg30 mg30 mg

Obs!

  • Tabletterna ska svĂ€ljas hela.
  • Den glömda dosen ska tas sĂ„ snart som möjligt. Om det Ă€r nĂ€ra tiden för nĂ€sta dos, ska den glömda dosen inte tas.
  • Erfarenheten saknas om. barn och ungdomar under 18 Ă„r.

Eventuella biverkningar

Mycket vanlig (över 10%)

Diarré, IllamÄende

Vanlig (1-10%)

Minskad aptit, trötthet

BuksmÀrtor, krÀkningar, sur repetition

Hosta, HĂžfeber

RyggsmÀrta smÀrta~~POS=HEADCOMP

Depression, huvudvÀrk, migrÀn, sömnlöshet

luftvÀgsinfektion

Mindre vanliga (0,1-1%)

Blödning i mag-tarmkanalen

SjÀlvmordstankar eller beteenden *

ÖverkĂ€nslighet

* Över hela vĂ€rlden, fram till mars 2016 rapporterades totalt 65 fall av sjĂ€lvmord och sjĂ€lvmord, inklusive 5 sjĂ€lvmord begagna. I 32 av 65 rapporter rapporterades en förbĂ€ttring efter behandlingen avbröts. FrĂ„n marknadsföringen i januari 2015 till 20 mars 2016, ca. 105 000 patienter ordinerades OtezlaÂź.



graviditet

AnvÀnd inte.

amning

Bör inte anvÀndas pÄ grund av bristande kunskap.

trafik

Ingen varning.

givarblod

Falla inte. 2-dagars karantÀn. Om du kan förlora beror dock pÄ din sjukdom.

effekt

OtezlaŸ minskar effekten av substanser (innefattande TNF-α, IL-23, IL-17 och andra sÄ kallade inflammatoriska cytokiner) som pÄverkar aktiviteten sjukdomen i psoriatisk artrit och psoriasis.


farmaceutiska former

tabletter. 1 tablett (filmdragerad) innehÄller 10 mg, 20 mg eller 30 mg apremilast.


SĂ€rskilda varningar

  • Underviktiga patienter bör ha sin vikt kontrollerad regelbundet, eftersom preparatet kan minska aptiten.
  • Tala om för din lĂ€kare omedelbart om du som patient (eller vĂ„rdgivare eller vĂ„rdgivare till patienten) upplever förĂ€ndringar i beteende eller humör, eller tecken pĂ„ sjĂ€lvmordstankar under behandling med OtezlaÂź.

AnvÀndning av andra lÀkemedel

Det Àr viktigt att informera din lÀkare om alla lÀkemedel du tar.

Epilepsi medel (t ex karbamazepin, fenobarbital, fenytoin), rifampicin (tuberkulos agent) och naturlÀkemedel innehÄllande johannesört minskar effekten av OtezlaŸ.

Grants, leverans, förpackning och priser

subventionerutlÀmningDoseringsform och styrkapackningPris i kr.
filmdragerade tabletter10 + 20 + 30 mg4 + 4 + 19 st. (Blister)3.680,25
filmdragerade tabletter30 mg56 st. (Blister)7.615,10


fÀrgÀmnen

JÀrnoxider och jÀrnhydroxider (E172)

Titandioxid (E171)



OtezlaÂź

FAQ - 💬

❓ What exactly does Otezla do?

👉 Otezla (apremilast) treats psoriasis and psoriatic arthritis by regulating inflammation within the cell. It inhibits an enzyme known as phosphodiesterase 4 (PDE4). This enzyme controls much of the inflammatory action within cells, which can affect the level of inflammation associated with psoriatic disease.

❓ What are the side effects of taking Otezla?

👉 The most common side effects of Otezla include diarrhea, nausea, upper respiratory tract infection, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

❓ Why does Otezla cause weight loss?

👉 Many people lose weight when taking Otezla. This can occur partly because of how the drug works, and partly because of some of its more common side effects. Otezla's possible side effects include diarrhea, nausea, vomiting, and reduced appetite. Many people who take Otezla lose weight due to these side effects.

❓ What kind of drug is Otezla?

👉 Generic Name: apremilast This medication is used to treat a certain type of arthritis (psoriatic arthritis). Apremilast is also used to treat a certain type of skin condition (moderate to severe plaque psoriasis). Apremilast belongs to a class of drugs known as phosphodiesterase 4 (PDE4) inhibitors.

❓ Is Otezla hard on the liver?

👉 There is no evidence that it is unsafe to drink alcohol while taking Otezla. This is most likely because Otezla is not known to cause liver problems, unlike some other medications used to manage psoriasis.

❓ Who should not take Otezla?

👉 Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of complications from having severe diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur. Otezla is associated with an increase in depression.

❓ Can you stop Otezla cold turkey?

👉 Official answer. Otezla does not cause withdrawal symptoms when stopped, so it may be stopped suddenly, but there have been reports of people experiencing gastrointestinal complaints such as constipation, after they have stopped Otezla.

❓ Does Otezla weaken the immune system?

👉 Yes, Otezla is an immunosuppressant. This means the drug lowers (suppresses) the activity of your immune system. Specifically, Otezla works by reducing inflammation that's caused by an overactive immune system.

❓ What is Otezla used to treat?

👉 What is Otezla? Otezla ( apremilast) is a tablet taken twice a day that is used to lower inflammation in the treatment of specific types of psoriatic arthritis, plaque psoriasis and Behçet's disease . Otezla works by inhibiting an enzyme within your immune system that can affect certain cells and contribute to inflammation in the body.

❓ Is Otezla approved for psoriatic arthritis?

👉 APPROVED USES OtezlaÂź (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate. Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

❓ What is the difference between Otezla and close?

👉 Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis. Otezla is a prescription medicine approved for the treatment of adult patients with oral ulcers associated with Behçet’s Disease. Otezla is a different kind of treatment Close.

❓ Is diarrhea a side effect of Otezla?

👉 Diarrhea is one of the most common side effects of Otezla. For most people, this side effect isn’t severe. It usually goes away within about 2 weeks after starting Otezla, as your body gets used to the medication. For most people who took Otezla in studies, diarrhea wasn’t severe.


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